BMS5002 Infectious Diseases Assessment Two : Diagnostic Algorithm 2026 | BCU

BMS5002 Infectious Diseases Assessment Two

Assessment Brief

Assessment Information 

Assessment Task 

This assessment is based upon diagnostic algorithms concerning the diagnosis of meningoencephalitis. This is supported by the lecture content provided within the module. Further support and information will be provided in the workshop and lab sessions. This assessment is based on case studies of meningoencephalitis. Each group will be given their own case study. Any deviation from the correct case study will result in a non-submission. CAREFULLY read the case report and write a report addressing the points provided, using the algorithm and Table provided. 

You should write up to 1000 words +/- 10%. Assignments must be written using the Cadmus platform in Moodle. No other formats will be allowed. Cadmus contains a fully functioning editor that is very similar to using Microsoft Word. Avoid copying and pasting material into Cadmus from other programs, as this will be highlighted to the markers. Instead, write everything in your own words directly into Cadmus. You may include figures, tables and/or diagrams. In workshops, you will be shown how to use Cadmus to write your assignment. When writing your assignment, do not include the information provided in the case scenario that you have been sent, as you will use up your word limit. 

Completion of this assessment will address the following learning outcomes: 

• Explain how the different systems within the body function to prevent infections occurring and how pathogens have evolved strategies to overcome the body’s defences.
• Summarise the key clinical tests for identifying a range of microbes and the associated therapeutic strategies.

Submission Information 
 
Present any written aspects of the assessment using font size 11 and using 1.5 spacing to allow for comments and annotations to be added by the markers. 
 
Complete the appropriate cover sheet for this assessment and append your work.   
 
This assessment will be marked anonymously and should show your student number only.   
 
Submit this coursework assessment task via Moodle-

Meningoencephalitis Algorithm

Table 1: Expected CSF Findings in Bacterial versus Viral versus Fungal Meningitis 

Case Study One – Groups 1-3

Using the flowchart and expected CSF findings in Table 1, trace a diagnostic pathway for a 65-year-old patient presenting with acute confusion, fever, and a new-onset seizure. The initial CSF analysis shows it is clear, has lymphocytic pleocytosis [ 265 WBC (cell/µl) ], raised protein (300 mg/dl), and glucose levels were at 65 mg/dL. 

Flowchart Deconstruction: 25 marks

• Justify the rationale behind the sample type chosen and primary testing (e.g., cell counts / Gram stain)
• From the flow chart/algorithm, analyse and explain which pathogen(s) may be responsible, and why you have excluded the others. Critically evaluate the test(s) chosen to identify the pathogen. 

Initial test results indicated that the pathogen(s) listed from the algorithm and what you thought may have caused the infection are not correct. Additional information states that the patient has just come from a holiday in South America (Brazil), where there is an unusually high population of  Ae.egypti  and Culex spp. 

• Critically explain what pathogens could be responsible but are not listed in the algorithm, and where you would add these pathogens within the algorithm. What diagnostic tests would you recommend and why? 25 marks

Algorithm Improvement Proposal: 20 Marks

Based on recent advances in diagnostic technology (e.g., multiplex PCR panels, metagenomic next-generation sequencing), propose a specific modification to the algorithm. Where would you incorporate the new technology? Justify your proposal by discussing how it would improve diagnostic speed, accuracy and cost-effectiveness 

Pathogenicity of the disease: 

• Discuss and explain the viral tropism and pathophysiology of HSV encephalitic infection 
  20 marks
• References, Grammar, Scientific terminology: 10 Marks

Case Study Two – Groups 4-6

Using the flowchart and expected CSF findings in table 1, trace a diagnostic pathway for a 29-year-old patient presenting symptoms such as neck pain, fever, nausea, photophobia and personality change. Complete blood work illustrated anaemia,  lymphopenia without leukopenia, and serology indicated HIV infection with viremia and decreased CD4 count (<20 cells/uL). CSF and blood were taken. CSF was clear, WBC was 462 (cell/µl), protein was 230 mg/dl, and glucose levels were at 45 mg/dL. 

Flowchart Deconstruction: 25 Marks

• Justify the rationale behind which algorithm was used. The sample type chosen, as well as primary testing (e.g., cell counts / Gram stain)
• From the flow chart/algorithm, analyse and explain which pathogen(s) may be responsible, and why you have excluded the others. Critically evaluate the test(s) chosen to identify the pathogen.

Initial test results indicated that the pathogen (s) listed from the algorithm and what you thought may have caused the infection are not correct. However, the suspected organism is not a virus; blood cultures grew a fungus, and further information indicated IV drug 

• Critically explain what pathogen(s) could be responsible but are not listed in the algorithm,  and where you would add these pathogens within the algorithm. What diagnostic tests would you recommend and why; 25 Marks

Algorithm Improvement Proposal: 20 Marks

• Based on recent advances in diagnostic technology (e.g., multiplex PCR panels, metagenomic next-generation sequencing), propose a specific modification to the algorithm. Where would you incorporate the new technology? Justify your proposal by discussing how it would improve diagnostic speed, accuracy and cost-effectiveness

Pathogenicity of the disease 20 Marks

• Discuss and explain the infection and pathophysiology of Cryptococcus neoformans CNS infection 
• References, Grammar, Scientific terminology: 10 Marks

Marking Criteria

This assessment addresses the following learning outcomes (LOs): 

• Explain how the different systems within the body function to prevent infections occurring and how pathogens have evolved strategies to overcome the body’s defences
• Summarise the key clinical tests for identifying a range of microbes and the associated therapeutic strategies