BIOM5708 Advanced Molecular Biology and Genomics Coursework De Montfort University

1. Answer all parts of the question

A 45-year-old patient has been diagnosed with major depressive disorder and is prescribed the antidepressant  medication fluoxetine (Prozac). During their initial clinic visit, a pharmacogenetic test revealed that the patient has a CYP2D6 genotype of.
Answer all parts of the question. 

1. Interpret the patient's CYP2D6 genotype and explain the expected impact on fluoxetine metabolism  and response. 

2. Discuss the possible laboratory techniques to detect the CYP2D6 genetic variants. 

3. Reflect on how this case highlights the value of incorporating pharmacogenetics to provide patients  with personalised, optimised medication therapy.  

2. Answer all parts of the question  

A 35-year-old Black African woman is pregnant with her first child. However, the pregnancy is considered a  high risk as she was diagnosed with ovarian cancer during pregnancy. In addition, her medical history revealed  that a faulty BRCA gene is inherited in her family. The patient has accepted genetic testing to detect any  chromosomal abnormalities or genetic changes to aid in evaluating prognosis and treatment strategies for  her. She has also received an amniocentesis analysis to investigate any possible genetic abnormality of the  foetus. 

a) Critically discuss how karyotyping can be used in determining the subtype and stage of ovarian cancer 

b) Critically evaluate any alternative technique to support results from karyotyping, highlighting its  advantages and disadvantages 

c) Critically discuss how cancer diagnosis and treatment can affect the reproductive health or fertility of  women

3. Answer all parts of the question

Antimicrobial peptides (AMPs) contribute to the first line of defence against various pathogens.  

a) Evaluate the advantages and disadvantages of AMPs over antibiotics in therapeutics.

b) Review the role of AMPs in airway-associated lung diseases. 

c) Discuss how AMPs modulate host immunity.