CASP Checklist -11 Questions To Help You Make Sense Of A Randomised Controlled Trials

Published: 07 Aug, 2025
Category Assignment Subject Education
University Module Title CASP Randomised Controlled Trials Checklist

(A) Are The Results Of The Trial Valid?

Screening Questions

1. Did the trial address a clearly focused issue?

HINT: An issue can be ‘focused’ In terms of

  • The population studied
  • The intervention given
  • The comparator given
  • The outcomes considered

Yes Can’t tell No

2. Was the assignment of patients to treatments randomised?

HINT: Consider

  • How was this carried out?
  • Was the allocation sequence concealed from researchers and patients?

Yes Can’t tell No

3. Were all of the patients who entered the trial properly accounted for at its conclusion?

HINT: Consider

  • Was the trial stopped early?
  • Were patients analysed in the groups to which they were randomised?

Yes Can’t tell No

  • Is it worth continuing?

Detailed Questions

4. Were patients, health workers and study personnel ‘blind’ to treatment?

HINT: Think about

  • Patients?
  • Health workers?
  • Study personnel?

Yes Can’t tell No

5. Were the groups similar at the start of the trial?

HINT: Look at

  • Other factors that might affect the outcome such as age, sex, social class

Yes Can’t tell No

6. Aside from the experimental intervention, were the groups treated equally?

Yes Can’t tell No

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(B) What Are The Results?

7. How large was the treatment effect?

HINT: Consider

  • What outcomes were measured?
  • Is the primary outcome clearly specified?
  • What results were found for each outcome?

Yes Can’t tell No

8. How precise was the estimate of the treatment effect?

HINT: Consider

  • What are the confidence limits?

Yes Can’t tell No

(C) Will The Results Help Locally?

9. Can the results be applied in your context? (or to the local population?)

HINT: Consider whether

  • Do you think that the patients covered by the trial are similar enough to the patients to whom you will apply this?, if not how to they differ?

Yes Can’t tell No

10. Were all clinically important outcomes considered?

HINT: Consider

  • Is there other information you would like to have seen?
  • If not, does this affect the decision?

Yes Can’t tell No

11. Are the benefits worth the harms and costs?

HINT: Consider

Even if this is not addressed by the trial, what do you think?

Yes Can’t tell No

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