A lab scale 2L bioreactor operates at a volumetric productivity of 4 g L-1 h1 and is integrated: Chemical Engineering Assignment Brief

Published: 12 Mar, 2025
Category Assignment Subject Engineering
University ____ Module Title Chemical Engineering

Questions

1. A lab scale 2L bioreactor operates at a volumetric productivity of 4 g L-1 h1 and is integrated with a cylindrical 400 mL separator (Figure 1) with an L/D ratio = 4. The residence time in the separator is 16 min. The system described is characterised by Re = 105. The fermentation broth is characterised by μa = 0.25 Pa.s, p = 1050 kg m23.

a) Calculate the current length and diameter of the separator in operation.
b) If residence time is reduced to 8min will there be an interference on settling?

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2. Propose an approach for scaling up the lab scale separator described above for a bioreactor volume of 10 m3, operating at the same volumetric productivity and a maximum residence time of 16 min (see Figure 1).

  • Discuss your considerations for the basis of performing the scale up design.
  • State any relevant parameters for design and / or verification.
  • Detail any further measurements which would be needed to support the scale up design.

3. Propose a downstream procedure to ensure that the final product, taken from the separator and having the composition shown in Table 1, meets the specifications given in Table 2 so it is suitable to sale to customers. Aim to provide a process that can be applied industrially for as low a price as possible. State any assumptions and trade-offs/compromises in the design.

Chemical Engineering

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Chemical Engineering

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